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August 18th, 2022

Press Release

Capnopharm is proud to announce its selection as Finalist of the prestigious Reuters Pharma Europe Award 2022 for its Cancer drug delivery innovation – Capnodrug® – in the Health Entrepreneur Award category. CapnoPharm was shortlisted out of a pool of 800 applicants, including some of the world’s leading pharmaceutical companies, and is eagerly awaiting the awards ceremony in London on 17th November 2022.

Each year, over one million patients worldwide are diagnosed with peritoneal cancer – a condition often consecutive to stomach, bowel or gynecological cancer. For most patients, there is no truly effective therapy. Systemic chemotherapy is less effective than in other indications. There is no chemotherapeutic drug approved for intraperitoneal drug delivery.

The awarded CapnoDrug® technology is a patented drug delivery platform with several benefits against peritoneal cancer : homogenous distribution of the drug within the abdominal cavity, direct access to the tumor site, sustained drug release and enhanced delivery to the tumor cells. CapnoDrug® can also be used for non-viral and viral gene delivery.

In May 2022, Capnopharm was already an acclaimed winner of the German Innovation Awards in the Medical Technologies Category. Reaching the finals of the Pharma Europe Award 2022 marks the sixth award achievement for CapnoPharm and its sister company Capnomed since 2020.

Capnopharm is committed to advancing peritoneal cancer care and improving the health and well-being of patients around the world – for the greatest possible quality of life.

For more on Pharma Awards Europe 2022 please visit.

Please visit

Contact : S. Laurent, VP Global Sales & Business Development,

Tübingen, July 1st, 2022

Press Release

Capnopharm GmbH today announced it has entered into an asset purchase agreement to acquire all operating assets from Capnomed GmbH.

Founded in 2015, Capnomed has played an essential role in developing Pressurized IntraPeritoneal Aerosol  Chemotherapy (PIPAC™). PIPAC™ is a new, minimally-invasive method of treating peritoneal cancer delivering novel therapies to the entire affected tissue with precision and safety. Capnomed successfully introduced the  medical device Capnopen™, the gold standard of laparoscopic nebulizers. Capnomed created a new market for intraperitoneal drug delivery, and developed PIPAC™’s ecosystem through academic collaborations, support for translational research and clinical studies, and unrestricted educational grants to peer-reviewed journals and scientific societies.

“One million patients develop peritoneal cancer globally every year. There is no truly effective therapy. Capnopharm’s vision is to change this and to shape the future of peritoneal cancer care”, said Ranjita Sahoo, PhD, Capnopharm’s Chief Scientific Officer. First randomized data presented at ASCO 2022 showed superiority  of PIPAC™ with cisplatin and doxorubicin over systemic intravenous chemotherapy in platin-resistant ovarian cancer. Compared to intravenous chemotherapy, PIPAC™ had better response rate and improve quality of life  with minimal morbidity 1. There are at least 40 further registered clinical trials evaluating PIPAC™’s safety and efficacy in various indications, including a collaborative PIPAC™ trial with the Capnopen™ in the USA 2. “Capnopharm will increasingly focus on next-generation strategies to overcome the challenges of existing  therapies of peritoneal cancer. This will include repurposing and reformulating generic drugs, exploring nanotechnology, immunotherapy, cytolytic virotherapy and mRNA as new-era therapy platforms “, adds Dr. Sahoo.

“PIPAC™ will ultimately benefit to the patients. The acquisition of Capnomed’s assets will generate unique  synergies at the crossroads of medical need, engineering and pharmaceutical sciences. This acquisition will  further diversify our business, create operational synergies, facilitate market access and enhance Capnopharm’s value” said Prof. Dr. Marc A. Reymond, MD MBA, Capnopharm’s CEO.

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Potential customers can contact S. Laurent, VP Global Sales & Business Development,

About Capnopharm

Capnopharm GmbH (registered in Stuttgart, Germany, HRB 783092, is a privately-owned company with headquarters in Tübingen. Capnopharm’s products are sold in more than 40 countries through a combination of direct sales, distributors and a global footprint of 100+ leading cancer hospitals worldwide.


Capnopen™ and PIPAC™ are protected trademarks detained by Capnopharm. Capnopen™ is CE-certified and registered in 40+ countries globally. To Capnopharm’s knowledge, no drug is approved for intraperitoneal  delivery: PIPAC™ is an off-label procedure under the sole responsibility of the treating physician. The Capnopen™ device is not available for sale in the USA. Capnopharm GmbH has based forward-looking statements on its current assumptions, expectations and projections about future events. Unknown or unpredictable factors could have material adverse effects on future results, performance or achievements. In light of these risks, uncertainties, assumptions and factors, the forward-looking events discussed in this press release may not occur. Capnopharm GmbH is not under any obligation and does not intend to update or revise any of the forward-looking statements contained in this press release to reflect circumstances existing after the date of this press release and related conference call or to reflect the occurrence of future events.


Breaking news from ASCO 2022 : PIPAC with cisplatin and doxorubicin is superior to intravenous chemotherapy in platin-resistant ovarian cancer.

On June 4 th 2022, at the Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, Prof. Somashekhar from Manipal Comprehensive Cancer Center, Bangalore, India, presented interim results of a randomized control trial comparing Pressurized intraperitoneal aerosol chemotherapy (PIPAC) versus intravenous chemotherapy (IV) in unresectable peritoneal metastases  secondary to platinum-resistant ovarian cancer:

These results show that PIPAC is safe and feasible for women with unresectable platinum-resistant ovarian cancer. PIPAC showed better objective response rates and improved quality of life when compared to the chemotherapy arm, with acceptable morbidity.

The primary endpoint was the objective response rate, assessed with RECIST 1.1 between PIPAC and IV chemotherapy arm. Secondary endpoints evaluated the two groups’ quality of life (QLQ C-30) and morbidity (CTCAE 4.0 and Clavien dindo). PIPAC was done with a dose of cisplatin of 15 mg /m2 and doxorubicin of 3 mg/m2. The choice of IV chemotherapy was at the discretion of the treating physician.

Forty patients underwent 105 PIPAC applications, with nearly 25 (62.5%) completing three cycles. Forty patients underwent IV chemotherapy same time, with nearly 23 (57.5%) having received at least five cycles. Mean age 57.3±8.05, PCI 24.45±6.39, with nearly 45.5% of patients had previous surgery and 72.5% of patients having received at least two lines of prior chemotherapy, and nearly 60% having ascites. The objective response rate is 66.6% versus 22.5%, grade 3-4 events were 10.0% vs. 35.7% in PIPAC and IV arm respectively. Histological regression was seen in 67.5% of patients with three cycles of PIPAC. Functional, symptom and global health scores at day 120 were significantly better with the PIPAC arm when compared to the IV arm.

This study is a milestone in delivering high-level medical evidence for the efficacy and excellent tolerability of PIPAC for treating peritoneal metastasis.

Reference:, consulted on June 7th , 2022