Intraperitoneal delivery as pressurized aerosols can synergistically be optimized by two factors : drug and device. The case study presented here clearly demonstrates that the surface engineered nanoparticles designed for the peritoneal cavity microenvironment can create a superior impact when combined with a medical device technology such as PIPAC^® or ePIPAC. We compared cationic and anionic nanoparticles with crossed over medical technology group to show enhanced tissue uptake in an established ex vivo model of the human peritoneum. Medical science can work on both to get better pharmacological effects.